Towards a tissue-level understanding of homeostasis and inflammation

Monday, 1 June 2026, 12pm to 1pm

Immune responses unfold within tissues whose architecture and composition fundamentally shape inflammation and its resolution. Understanding these processes requires integrating spatial tissue structure with cellular dynamics and function. In this seminar, we will explore advanced imaging and computational approaches that connect single-cell behavior with tissue-level organization. By combining multiplex 3D microscopy, quantitative analysis, and in vivo functional imaging, we examine how tissue macrophages interact with stromal networks to sustain homeostasis or promote dysfunction. Through this framework, we will discuss how spatial tissue organization may set local inflammation thresholds and govern the shift from physiological repair to pathological disease.

Speaker(s): Prof. Dr. med. Stefan Uderhardt (University Hospital Erlangen)

Venue: Kennedy Institute of Rheumatology - Kennedy Lecture Theatre - Kennedy Lecture Theatre Kennedy Institute of Rheumatology Headington Oxford Oxfordshire OX3 7FY United Kingdom

Department: Kennedy Institute of Rheumatology (Unit)

Organiser: Tess Lawless

Host: Professor Irina Udalova