Extrachromosomal DNA (ecDNA): Cancer's Dynamic Circular Genome

Wednesday, 3 June 2026, 12pm to 1pm

Paul Mischel, M.D. is the Fortinet Founders Professor, Vice Chair for Research for the Department of Pathology, and Deputy Director of Translational Science and an Institute Scholar at Sarafan ChEM-H, Stanford University. Mischel, who leads the eDyNAmiC Cancer Grand Challenges Team, has made important contributions to the scientific understanding of extrachromosomal DNA (ecDNA) in cancer development, progression, and therapeutic resistance and the development of innovative techniques to study ecDNA. His research, published in Nature, Science, and Cell, and highlighted in a recent profile in Science Magazine (https://www.science.org/con[…]st-leads-effort-target-them), has catalyzed a paradigm shift in the fundamental understanding of cancer biology, and his leadership has opened a new field that has led to the development of new drugs being tested in the clinic. Mischel is a member of the National Academy of Medicine, a Fellow of the AACR Academy, and Past-President of the American Society for Clinical Investigation. He is an academic co-founder of Boundless Bio and Alterris Oncology.

Paul Mischel M.D., FAACR
Fortinet Founders Professor
Professor, By Courtesy, Department of Neurosurgery
Vice Chair for Research, Department of Pathology
Institute Scholar and Deputy Director, Translational Science, Sarafan ChEM-H
Stanford University

Speaker(s): Professor Paul Salomon Mischel (Stanford University)

Series: Molecular Haematology Unit, WIMM

Venue: MRC Weatherall Institute of Molecular Medicine - WIMM Seminar room - WIMM Seminar room MRC Weatherall Institute of Molecular Medicine Headington Oxford Oxfordshire OX3 9DS United Kingdom

Department: Weatherall Institute of Molecular Medicine (Unit)

Organiser: Beatriz Hirt-Font

Host: KJ Patel

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