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SUMMARY:DPAG BURDON SANDERSON PRIZE LECTURE 2026: 'Higher-order transient 
 structures (HOTS) and the principle of dynamic connectivity in membrane si
 gnaling'
DTSTART;TZID=Europe/London:20260609T160000
DTEND;TZID=Europe/London:20260609T170000
DTSTAMP:20260523T075454Z
UID:03e87463-1a22-f111-8341-70a8a54b42b9
CREATED:20260317T160019Z
DESCRIPTION:Cells convey signals (information) across their membranes thro
 ugh the interactions of membrane proteins that communicate with each other
 \, forming what are called signal pathways\, akin to the components in an 
 electronic circuit. But cell membranes are 2-dimensional liquids in which 
 diffusion dominates\, raising the questions how do the components connect\
 , and why do coexisting pathways not interfere with each other? In this pr
 esentation I will show you that many membrane proteins self-assemble into 
 higher order transient structures (HOTS). Because HOTS are formed through 
 specific protein interactions\, they must be genetically encoded macromole
 cular units. I will explain how HOTS can (1) underlie a dynamic connectivi
 ty by tying together in a statistical manner the components of a signal pa
 thway and (2) permit multiple signal pathways to coexist in the cell membr
 ane.\n\nSPEAKER BIOGRAPHY\n\nRoderick MacKinnon received the 2003 Nobel Pr
 ize in Chemistry for his work on the structure and operation of ion channe
 ls. He is the John D. Rockefeller Jr. Professor and head of the Laboratory
  of Molecular Neurobiology and Biophysics at The Rockefeller University\, 
 where he studies the principles of electricity production in living cells 
 through analysis of ion channel structure and function. He received an MD 
 from Tufts University School of Medicine and completed an internal medicin
 e residency at the Beth Israel Hospital Boston. Following postdoctoral stu
 dies with Christopher Miller at Brandeis University\, he joined the facult
 y at Harvard Medical School from 1989 to 1995 before moving to The Rockefe
 ller University in 1996 and becoming a Howard Hughes Medical Institute (HH
 MI) Investigator in 1997.
LAST-MODIFIED:20260410T114503Z
LOCATION:Sherrington Building - Blakemore Lecture Theatre\, Blakemore Lect
 ure Theatre Sherrington Building off Parks Road Oxford Oxfordshire OX1 3PT
  United Kingdom
SPEAKER:Professor Roderick MacKinnon (The Rockefeller University)
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