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SUMMARY:What dominates fluctuations of cellular growth rate?
DTSTART;TZID=Europe/London:20260529T110000
DTEND;TZID=Europe/London:20260529T120000
DTSTAMP:20260527T025444Z
UID:0a99c4c3-8e44-f111-bec7-7c1e52046848
CREATED:20260430T121900Z
DESCRIPTION:Many cells exhibit exponential growth not only at the populati
 on level but also at the single-cell level. However\, single-cell growth r
 ates fluctuate over time. We distinguish between two conceptually distinct
  sources of growth rate fluctuations: intrinsic continuous fluctuations re
 sulting from intracellular processes\, and fluctuations that originate at 
 division events\, which we refer to as kicks. We use a simple model to des
 cribe single-cell growth and identify the signatures of continuous noise a
 nd division kicks. To infer the true biological behavior reliably from exp
 eriments\, it is crucial to account for measurement noise. We derive analy
 tical expressions for the statistics of meaningful observables\, accountin
 g for continuous fluctuations\, division kicks\, and measurement noise. Im
 portantly\, we find that ignoring measurement noise can lead to incorrect 
 biological conclusions. Our results provide insights into how different so
 urces of growth rate variability and measurement errors influence observed
  cell size dynamics\, offering an interpretable framework for analyzing e
 xperimental data in cellular biology.
LAST-MODIFIED:20260430T122044Z
LOCATION:Mathematical Institute - L4\, L4 Mathematical Institute Woodstock
  Road Oxford Oxfordshire OX2 6GG United Kingdom
SPEAKER:Dr Roi Holtzman (Dept of Physics\, University of Oxford)
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