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DTSTART:19700329T010000
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SUMMARY:Modulating\, Not Depleting: Engineered Bacteria for the Collagen B
 arrier in Solid Tumors
DTSTART;TZID=Europe/London:20260716T121500
DTEND;TZID=Europe/London:20260716T131500
DTSTAMP:20260713T133504Z
UID:0d32adc0-a97e-f111-ab0f-6045bdc13891
CREATED:20260713T105819Z
DESCRIPTION:The dense\, collagen-rich extracellular matrix (ECM) of solid 
 tumors\, a hallmark it shares with fibrotic disease.  obstructs the transp
 ort of drugs\, nanomedicine\, and immune cells\, and correlates with poor 
 therapeutic response. I will present our strategy to overcome this barrier
  not by depleting the ECM\, but by locally modulating it with engineered t
 umor-targeting bacteria. Our collagenase-secreting Nanoscale Bacteria-Enab
 led Autonomous Delivery System (NanoBEADS) penetrates 1.6-fold deeper in c
 ollagen-rich tumors and improves chemotherapy response by 1.5-fold relativ
 e to chemotherapy alone — all while preserving collagen architecture and
  without promoting tumor cell out-migration. Altogether\, these results po
 sition localized matrix modulation as a safer alternative to depletion\, w
 ith implications for treating solid tumors and fibrosis.
LAST-MODIFIED:20260713T110134Z
LOCATION:Kennedy Institute of Rheumatology - Kennedy Lecture Theatre\, Ken
 nedy Lecture Theatre Kennedy Institute of Rheumatology Headington Oxford O
 xfordshire OX3 7FY United Kingdom
SPEAKER:Prof. Bahareh Behkam (Virginia Tech)
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