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SUMMARY:Emergent phenomena in protein complexes out of equilibrium: from t
 opologically-protected states to computation
DTSTART;TZID=Europe/London:20261016T110000
DTEND;TZID=Europe/London:20261016T120000
DTSTAMP:20260813T175755Z
UID:12a21806-086b-f111-ab0d-7c1e52046c40
CREATED:20260618T112248Z
DESCRIPTION:Protein complexes\, typically made up of a small number of ide
 ntical subunits\, are very common in biology. These subunits can additiona
 lly undergo post-translational modifications\, such as phosphorylation and
  dephosphorylation\, resulting in a high dimensional state space for the p
 rotein complex. Importantly\, such modifications are catalyzed by enzymes 
 that are driven out of equilibrium by the consumption of a fuel such as AT
 P. I will discuss\, from a theoretical perspective\, how very simple enzym
 e-catalyzed operations at the single subunit level can result in emergent 
 behaviour at the level of the entire protein complex. First\, I will discu
 ss how topologically-protected edge currents emerge and become enhanced in
  arbitrarily high-dimensional stochastic systems representing the state of
  the complex\, extending previous results for two-dimensional stochastic s
 ystems [1]. Second\, I will discuss how enzymes that act on a subunit in a
  context-dependent manner provide a molecular implementation of stochastic
  cellular automata\,  that can be exploited to engineer molecular-scale co
 mputing devices\, such as an error-tolerant memory or a finite-state machi
 ne [2].\n\n[1] E. Tang\, J. Agudo-Canalejo\, and R. Golestanian\, Phys. Re
 v. X 11\, 031015 (2021)\n[2] J. Kocka\, K. Husain\, and J. Agudo-Canalejo\
 , PRX Life 4\, 013036 (2026)
LAST-MODIFIED:20260717T104449Z
LOCATION:Mathematical Institute - L4\, L4 Mathematical Institute Woodstock
  Road Oxford Oxfordshire OX2 6GG United Kingdom
SPEAKER:Dr Jaime Agudo-Canalejo (Dept of Physics & Astronom\, UCL)
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