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SUMMARY:Dissecting the Role of Phenotypic Variation in Cell Population Gro
 wth and Collective Self-Generated Chemotaxis
DTSTART;TZID=Europe/London:20261106T110000
DTEND;TZID=Europe/London:20261106T120000
DTSTAMP:20260813T175307Z
UID:13e3cd71-0897-f111-b8dc-7c1e521e2605
CREATED:20260813T111638Z
DESCRIPTION:Phenotypic variation is a ubiquitous feature of biological cel
 l populations\, even in genetically identical cells growing in uniform env
 ironments. Such variability can have profound consequences for population-
 level behaviour\, particularly under stress\, yet it is often neglected in
  classical modelling frameworks.\n\nIn the first part of this talk\, I con
 sider mathematical models of bacterial population growth that explicitly i
 ncorporate non-heritable variation in individual cell growth rates. I exam
 ine how phenotypic heterogeneity and environmental selection shape populat
 ion growth and the dynamics of phenotypic subpopulations. We derive theore
 tical results for population growth rates and compare them with prediction
 s from homogeneous models\, identifying regimes in which variability quali
 tatively alters population outcomes.\n\n In the second part of the talk\, 
 I turn to self-generated chemotaxis\, a collective process in which cells 
 modify their chemical environment to guide movement. Using a hybrid discre
 te–continuum model that couples stochastic cell motion with a continuum 
 description of the chemoattractant\, I investigate how phenotypic variatio
 n in motility\, sensing\, and chemical degradation affects the robustness 
 of collective migration. The results and tools developed have broader impl
 ications for collective behaviour in cell biology\, ecology\, and evolutio
 n.
LAST-MODIFIED:20260813T112046Z
LOCATION:Mathematical Institute - L4\, L4 Mathematical Institute Woodstock
  Road Oxford Oxfordshire OX2 6GG United Kingdom
SPEAKER:Prof John MacKenzie (Dept of Mathematics and Statistics\,Universit
 y of Strathclyde)
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