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SUMMARY:Protein biogenesis and quantity control at the ribosome
DTSTART;TZID=Europe/London:20260706T130000
DTEND;TZID=Europe/London:20260706T140000
DTSTAMP:20260616T112726Z
UID:14490e2b-345f-f111-a826-6045bd12f634
CREATED:20260603T100832Z
DESCRIPTION:The accurate and timely production of functional proteins is e
 ssential for cellular homeostasis. Dysregulation of protein synthesis is i
 mplicated in numerous human diseases\, including cancer and neurological d
 isorders. To maintain proteome integrity\, cells have evolved diverse mech
 anisms that control both the quality and quantity of proteins produced fro
 m the transcriptome. Among these\, co-translational surveillance of nascen
 t polypeptide chains (NCs) at the ribosome represents the earliest opportu
 nity for cells to facilitate proper protein folding and enforce quality co
 ntrol. However\, many co-translational pathways and their associated facto
 rs remain poorly understood\, due in part to the transient nature of these
  interactions and the lack of systematic approaches to study them. To addr
 ess this challenge\, our lab developed nascent chain interactor profiling 
 (NCIP)\, a method that enables proteome-wide identification of transient N
 C-interacting proteins during translation. In this talk\, I will present o
 ur characterization of two co-translational factors discovered using NCIP:
  an E3 ubiquitin ligase required for the clearance of misfolded nascent ch
 ains at the ribosome\, and a previously uncharacterized co-translational c
 haperone that plays a key role in the biogenesis of α-synuclein\, a patho
 genic protein implicated in Parkinson’s disease.
LAST-MODIFIED:20260603T101033Z
LOCATION:Dorothy Crowfoot Hodgkin Building - DCHB 20-138 Seminar Room 2\, 
 DCHB 20-138 Seminar Room 2 Dorothy Crowfoot Hodgkin Building off South Par
 ks Road Oxford Oxfordshire OX1 3QU United Kingdom
SPEAKER:Assistant Professor Zhewang Lin (Department of Biological Sciences
  at the National University of Singapore.)
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