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SUMMARY:Nuclear Mechanotransduction in Genome Integrity & Malignant Transf
 ormation
DTSTART;TZID=Europe/London:20260518T120000
DTEND;TZID=Europe/London:20260518T130000
DTSTAMP:20260512T052633Z
UID:1a442a53-d14a-f111-bec7-7ced8d9a5614
CREATED:20260508T113040Z
DESCRIPTION:Nuclear architecture coordinates patterns of gene expression a
 nd mediates cell identity and state. Nuclear architecture and shape are al
 so fundamentally altered in most cancers and these abnormalities are routi
 nely used to diagnose cancer and stage its aggressiveness. However\, the c
 auses and direct consequences of nuclear shape alterations in both healthy
  and diseased states have remained unclear. Using chromosome mis-segregati
 on driven aneuploidy and colorectal cancer (CRC) as models we have study t
 he roles of nuclear mechanics and deformation in cell state regulation\, m
 alignant transformation and cancer progression.  In my presentation I will
  discuss our recent research on how cells sense nuclear deformation and me
 chanical changes and how these mechanosignals are integrated with biochemi
 cal inputs to alter cell behaviors and tune disease outcome.
LAST-MODIFIED:20260508T113329Z
LOCATION:Kennedy Institute of Rheumatology - Kennedy Lecture Theatre\, Ken
 nedy Lecture Theatre Kennedy Institute of Rheumatology Headington Oxford O
 xfordshire OX3 7FY United Kingdom
SPEAKER:Dr. Yekaterina (Kate) Miroshnikova (Max Planck Institute for Molec
 ular Biomedicine\, Muenster\, Germany)
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