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SUMMARY:Decoding T cell specificity at scale
DTSTART;TZID=Europe/London:20260604T150000
DTEND;TZID=Europe/London:20260604T160000
DTSTAMP:20260527T025534Z
UID:1c03dce7-a33c-f111-88b5-7c1e52046959
CREATED:20260420T103015Z
DESCRIPTION:Dr. Stephanie Gaglione is a postdoctoral scholar in the Marson
  lab at the UCSF-Gladstone Institute of Genomic Immunology. She completed 
 her PhD at MIT with Michael Birnbam engineering high-throughput tools to s
 ynthesize and screen T cell receptors in the context of autoimmunity and c
 ancer. Her work introduced an approach to reconstruct thousands of T cell 
 receptors from sequences and map them against hundreds of antigens simulta
 neously\, identifying autoreactive T cells in vitiligo lesions with transc
 riptomic signatures akin to T cells in melanoma. She expanded on this appr
 oach to examine T cell cross-reactivity\, profiling millions of mutated TC
 Rs against many antigens simultaneously to map the TCR-antigen interface. 
 Stephanie is a Dunn School alum\, previously working with Omer Dushek.
LAST-MODIFIED:20260511T083849Z
LOCATION:Sir William Dunn School of Pathology - EPA Seminar Room\, EPA Sem
 inar Room Sir William Dunn School of Pathology South Parks Road Oxford Oxf
 ordshire OX1 3RE United Kingdom
SPEAKER:Dr Stephanie Gaglione (Gladstone Institute\, San Francisco\, USA)
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