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SUMMARY:Understanding the biological basis of schizophrenia using function
 al genomics and personalized disease models
DTSTART;TZID=Europe/London:20260602T093000
DTEND;TZID=Europe/London:20260602T103000
DTSTAMP:20260527T025422Z
UID:236c0bf4-833d-f111-88b4-7ced8d99a758
CREATED:20260421T131400Z
DESCRIPTION:In this talk\, I will present a translational research framewo
 rk for mechanism-based precision psychiatry that integrates human genetics
 \, functional genomics\, patient-derived cellular models\, and deep clinic
 al phenotyping. \nI will first outline how we link genetic variation to mo
 lecular\, cellular\, and network-level phenotypes using human iPSC-derived
  neuronal systems and multi-omics approaches. These models enable the iden
 tification of convergent biological mechanisms\, including synaptic regula
 tion and RNA processing\, that shape neuronal activity and network dynamic
 s. \nI will then present recent efforts to connect these mechanisms to pat
 ient-level variation by leveraging deeply phenotyped clinical cohorts alon
 gside large-scale genetic and endophenotypic datasets. \nFinally\, I will 
 discuss our efforts to model excitation-inhibition (E-I) in human neuronal
  co-cultures and operationalize it as quantitative endophenotype to unders
 tand inter-individual differences in treatment response. \nBy integrating 
 cellular models\, electrophysiological and neuroimaging measures\, we inve
 stigate how variability in E-I balance relates to response to antipsychoti
 c and other psychiatric medications\, including treatment resistance. \nTo
 gether\, this work outlines a scalable strategy to move from complex genet
 ics to biological mechanism and ultimately toward mechanistically grounded
  precision psychiatry.\n\nThis seminar is hosted in person at the Departme
 nt of Psychiatry\, in the Seminar Room. \nTo join online\, please use the 
 Zoom details below. \n\nhttps://zoom.us/j/94572787318?pwd=yQZc0eWXLehppqdt
 cdhbak2QTPy4V0.1\n\nMeeting ID: 945 7278 7318\n\nPasscode: 751629
LAST-MODIFIED:20260421T133039Z
LOCATION:Department of Psychiatry - Seminar Room\, Seminar Room Department
  of Psychiatry Headington Oxford Oxfordshire OX3 7JX United Kingdom
SPEAKER:Professor Michael Ziller (University of Münster)
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