BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//ox.ac.uk//NONSGML oxford.event//EN
X-WR-TIMEZONE:Europe/London
BEGIN:VTIMEZONE
TZID:Europe/London
X-LIC-LOCATION:Europe/London
BEGIN:DAYLIGHT
DTSTART:19700329T010000
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:19701025T020000
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
SUMMARY:Establishing the epigenome in early mammalian development
DTSTART;TZID=Europe/London:20260714T140000
DTEND;TZID=Europe/London:20260714T150000
DTSTAMP:20260626T210105Z
UID:244c3314-7d69-f111-ab0d-7c1e52046a23
CREATED:20260616T121540Z
DESCRIPTION:ABSTRACT\n\nDrastic transcription and epigenetic reprogramming
  occur during mammalian early embryogenesis. Deciphering the molecular eve
 nts underlying these processes is crucial for understanding how life reall
 y begins. Probing these questions was previously hindered by the scarce ex
 perimental materials that are available from early embryos. By developing 
 a set of ultra-sensitive chromatin analysis technologies\, we investigated
  epigenetic reprogramming during early mouse development for chromatin acc
 essibility\, histone modifications\, and 3D chromatin architecture. These 
 studies unveiled highly dynamic and non-canonical chromatin regulation dur
 ing the maternal-to-zygotic transition. Recently\, we also identified a nu
 mber of key transcription factors (TFs) that govern mammalian zygotic geno
 me activation (ZGA) and the first cell fate commitment. However\, how the 
 embryonic transcription program is established with the non-canonical\, im
 mature chromatin states\, and how the embryonic epigenomes are correctly r
 estored still remain enigmatic. In this talk\, I will present data on how 
 the embryonic epigenomes are properly re-established and how the embryonic
  transcription program is executed during this dramatic transition in earl
 y mammalian development.
LAST-MODIFIED:20260616T122109Z
LOCATION:Dorothy Crowfoot Hodgkin Building - DCHB 20-138 Seminar Room 2\, 
 DCHB 20-138 Seminar Room 2 Dorothy Crowfoot Hodgkin Building off South Par
 ks Road Oxford Oxfordshire OX1 3QU United Kingdom
SPEAKER:Dr. Wei Xie (TsienTang Professor & Vice Dean\, School of Life Scie
 nce\, Tsinghua University\, China)
END:VEVENT
END:VCALENDAR