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SUMMARY:DPAG HoD Seminar: 'New Discoveries in Heart: Vascular Signaling an
 d Heart Function'
DTSTART;TZID=Europe/London:20260522T130000
DTEND;TZID=Europe/London:20260522T140000
DTSTAMP:20260521T163731Z
UID:2aef0adf-8a23-f111-8342-7c1e52046959
CREATED:20260319T115804Z
DESCRIPTION:Recent work in my lab (and a few others) has provoked critical
  new questions about how heart\, brain and kidney -  the "heavy lifters" o
 f our biology  -  work!  While the answers to critical questions are elusi
 ve and the experiments are exceedingly difficult\, provocative findings wi
 ll be shown and discussed.  During this presentation\, I will focus on  th
 e heart.  In many ways\, it is the simplest of these three organs.  Despit
 e that simplicity\, there is a good chance that our answers will be a bit 
 wrong.  The primary controlling signal is electrical\, and it arises becau
 se of metabolic changes in ventricular myocytes.  My colleagues and I hypo
 thesize that such "electro-metabolic signaling" (EMS) significantly contri
 butes to blood flow regulation in heart.  Through EMS\, the metabolic acti
 vity of the heart muscle itself regulates the required blood flow.
LAST-MODIFIED:20260410T095725Z
LOCATION:Sherrington Building - Sherrington Library\, Sherrington Library 
 Sherrington Building off Parks Road Oxford Oxfordshire OX1 3PT United King
 dom
SPEAKER:Professor Jonathan Lederer (University of Maryland School of Medic
 ine)
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