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SUMMARY:Coupled activation and inactivation of endosomal Rab GTPases
DTSTART;TZID=Europe/London:20260609T100000
DTEND;TZID=Europe/London:20260609T110000
DTSTAMP:20260606T083333Z
UID:39c89aca-685e-f111-a826-7ced8d9a8d34
CREATED:20260602T095247Z
DESCRIPTION:Small GTPases in the Rab5 family maintain the composition and 
 function of the plasma membrane\, Golgi\, endosomes\, and lysosomes by coo
 rdinating vesicular trafficking between these organelles. The membrane tar
 geting of Rab5 regulators determines the precise contexts in which each Ra
 b5 GTPase governs endolysosomal trafficking events. Study of two exchange 
 factors that positively regulate Rab5-family GTPases in the model eukaryot
 e budding yeast have uncovered mechanisms linking Rab5 signaling to membra
 ne protein sorting and trafficking. We have discovered two unique modes of
  Rab regulation by the third Rab5 exchange factor in yeast\, the endosomal
  complex VINE. Despite being a positive regulator of Rab5-family proteins\
 , VINE triggers the inactivation of the major yeast Rab5 homolog. Findings
  from genome-wide protein proximity screening\, mutagenesis guided by pred
 ictive structural modelling\, and in vivo assays have given rise to a mode
 l in which VINE forms a novel protein phosphatase 1 complex that acts on k
 nown Vps21 negative regulators to promote Vps21 inactivation. We have also
  identified a minor Rab5 homolog as a target of positive regulation by VIN
 E. Its interactome implicates this GTPase in modulating endosomal membrane
  maturation and trafficking to the lysosome-related vacuole. This work rev
 eals a direct link between positive and negative Rab regulation which may 
 allow VINE to transform Rab signaling during endosomal protein trafficking
  events.
LAST-MODIFIED:20260602T095632Z
LOCATION:Dorothy Crowfoot Hodgkin Building - DCHB 20-138 Seminar Room 2\, 
 DCHB 20-138 Seminar Room 2 Dorothy Crowfoot Hodgkin Building off South Par
 ks Road Oxford Oxfordshire OX1 3QU United Kingdom
SPEAKER:Mia Frier (PhD Candidate\, Department of Medical Genetics\, The Un
 iversity of British Columbia)
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