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SUMMARY:Whole-body/organ Imaging with Single-cell Resolution  by Tissue-Cl
 earing Methods CUBIC
DTSTART;TZID=Europe/London:20260622T120000
DTEND;TZID=Europe/London:20260622T130000
DTSTAMP:20260527T012013Z
UID:4acb8a73-1359-f111-a825-6045bd12f634
CREATED:20260526T145916Z
DESCRIPTION:State-of-the-art tissue clearing methods provide unprecedented
 \, high-quality optical access to very large biological specimens from ind
 ividual organs to entire intact animals. When combined with light-sheet mi
 croscopy and image informatics\, currently available tissue-clearing metho
 ds including a hydrophilic tissue clearing method CUBIC\, allows us to per
 form whole-brain and whole-body imaging with sub-cellular resolution. In a
 ddition\, delipidation of biological specimens by tissue-clearing methods 
 enables whole-organ staining with specific antibodies\, which can be appli
 ed even to human biology and pathology. When combined with tissue clearing
 \, these labeling methods allow us to systematically extract structural an
 d functional information of complex mammalian organs. In this talk\, I wil
 l discuss how tissue-clearing and its related technologies have been succe
 ssfully integrated to create new biological insights and provide a perspec
 tive for future opportunities in organism-level synthetic biology and syst
 ems biology.
LAST-MODIFIED:20260526T152540Z
LOCATION:Kennedy Institute of Rheumatology - Kennedy Lecture Theatre\, Ken
 nedy Lecture Theatre Kennedy Institute of Rheumatology Headington Oxford O
 xfordshire OX3 7FY United Kingdom
SPEAKER:Prof. Hiroki Ueda (University of Tokyo and Kurume University)
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