BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//ox.ac.uk//NONSGML oxford.event//EN
X-WR-TIMEZONE:Europe/London
BEGIN:VTIMEZONE
TZID:Europe/London
X-LIC-LOCATION:Europe/London
BEGIN:DAYLIGHT
DTSTART:19700329T010000
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:19701025T020000
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
SUMMARY:Membrane impacts on ligand-receptor interactions at immune interfa
 ces
DTSTART;TZID=Europe/London:20260612T140000
DTEND;TZID=Europe/London:20260612T150000
DTSTAMP:20260611T005357Z
UID:4ba8cc1f-c13c-f111-88b5-7c1e52046959
CREATED:20260420T135923Z
DESCRIPTION:David Sansom is Professor of Transplant Immunology based at th
 e University College London (UCL) Institute for Infection\, Immunity and T
 ransplantation in London. He obtained his BSc and PhD in Bristol\, UK wher
 e he worked on HLA susceptibility to autoimmunity\, particularly in rheuma
 toid arthritis. He has held various positions at the University of Bath\, 
 University of Birmingham and latterly at UCL. \nDavid has expertise in hum
 an T cell biology especially in the areas of T cell costimulation\, immune
  regulation and Treg biology. His lab has a particular focus on understand
 ing the molecular and cellular biology that regulates the CTLA-4 immune ch
 eckpoint and its interactions with the PD-1 pathway. David’s lab discove
 red the molecular mechanism of CTLA-4 function termed “transendocytosis
 ” which provides a model for CTLA-4 as an effector molecule on regulator
 y T cells. He has been involved in the study of gene mutations in patients
  with CTLA-4 and LRBA deficiency\, who develop a variety of autoimmune con
 ditions due to impaired  regulatory T cell function. Recently\, his lab ha
 s identified key differences in the ligands CD80 and CD86 and how these in
 fluence both CTLA-4 and PD-1 immune checkpoints.
LAST-MODIFIED:20260520T120219Z
LOCATION:Medical Sciences Teaching Centre - Lecture Theatre\, Lecture Thea
 tre Medical Sciences Teaching Centre off South Parks Road Oxford Oxfordshi
 re OX1 3PL United Kingdom
SPEAKER:Prof David Sansom (UCL)
END:VEVENT
END:VCALENDAR