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SUMMARY:Multiscale modelling of dementia: from proteins to neuronal activi
 ty
DTSTART;TZID=Europe/London:20260511T133000
DTEND;TZID=Europe/London:20260511T143000
DTSTAMP:20260508T151923Z
UID:5696d98d-6219-f111-8342-7c1e522d9057
CREATED:20260306T135805Z
DESCRIPTION:Neurodegenerative diseases such as Alzheimer’s or Parkinson
 ’s are devastating conditions with poorly understood mechanisms and no k
 nown cure. Yet a striking feature of these conditions is the characteristi
 c pattern of invasion throughout the brain\, leading to well-codified dise
 ase stages visible to neuropathology and associated with various cognitive
  deficits and pathologies. This evolution is associated with the aggregati
 on of key toxic proteins. In this talk\, I will show how we use multiscale
  modelling to gain insight into this process  In particular\, by looking a
 t protein dynamics on the connectome\, we can unravel some of the universa
 l features associated with dementia that are driven by both network topolo
 gy and protein kinetics leading to changes in brain activity.\nAlain Gorie
 ly is a mathematician with broad interests in mathematical methods\, scien
 ces\, and engineering. He is well known for his contributions to fundament
 al and applied solid mechanics\, and\, in particular\, for the development
  of a mathematical theory of biological growth\, He joined the University 
 of Oxford in 2010 as the inaugural Statutory Professor of Mathematical Mod
 elling and fellow of St. Catherine's College. He is currently the Director
  of the Oxford Centre for Industrial and Applied Mathematics. In addition\
 , Alain enjoys scientific outreach based on problems connected to his rese
 arch including tendril perversion in plants\, twining plants\, umbilical c
 ord knotting\, whip cracking\, the shape of seashells\, visual illusions\,
  and brain modelling\,. For his contribution to mathematics and sciences\,
  he was elected Fellow of the Royal Society in 2022\, received the Society
  of Engineering Science Engineering Medal in 2024 and the David Crighton M
 edal in 2025. https://www.maths.ox.ac.uk/people/alain.goriely
LAST-MODIFIED:20260427T071505Z
LOCATION:The Life and Mind Building - Seminar room 7 & 8\, Seminar room 7 
 & 8 The Life and Mind Building South Parks Road Oxford   United Kingdom
SPEAKER:Prof Alain Goriely\, FRS
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