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DTSTART:19700329T010000
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SUMMARY:Genetic and Epigenetic Regulation of Synovial Fibroblasts in Rheum
 atoid Arthritis
DTSTART;TZID=Europe/London:20260720T120000
DTEND;TZID=Europe/London:20260720T130000
DTSTAMP:20260626T205952Z
UID:7138d927-dd6f-f111-ab0f-7c1e52046848
CREATED:20260624T145836Z
DESCRIPTION:This seminar will present recent advances in our understanding
  of the genetic and epigenetic regulation of synovial fibroblasts in rheum
 atoid arthritis (RA). The role of DNA methylation and chromatin organisati
 on in shaping pathogenic fibroblast phenotypes will be discussed\, and the
  role of RA genetic risk loci in altering fibroblast functions will be exp
 lored. Finally\, emerging approaches for identifying functional regulatory
  elements and candidate therapeutic targets will be discussed\, providing 
 a broad perspective on the genetic and epigenetic drivers of fibroblast ac
 tivation in RA.
LAST-MODIFIED:20260624T145947Z
LOCATION:Kennedy Institute of Rheumatology - Kennedy Lecture Theatre\, Ken
 nedy Lecture Theatre Kennedy Institute of Rheumatology Headington Oxford O
 xfordshire OX3 7FY United Kingdom
SPEAKER:Professor Caroline Ospelt (University of Zurich)
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