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SUMMARY:Kavli Oxford Lecture Award 2026 - Professor Jue Chen
DTSTART;TZID=Europe/London:20260608T160000
DTEND;TZID=Europe/London:20260608T170000
DTSTAMP:20260527T025514Z
UID:79bea704-2943-f111-bec6-7ced8d999d87
CREATED:20260428T173814Z
DESCRIPTION:Hosted by Kavli Oxford's Founding Director\, Professor Dame Ca
 rol Robinson\, Professor Chen will speak on 'ABC Transporters: how a commo
 n engine drives diverse functions'. The lecture will be followed by a drin
 ks reception at the Kavli Institute for Nanoscience Discovery in the Dorot
 hy Crowfoot Hodgkin Building.\n\n* Open to University of Oxford staff and 
 students only.\n\n* Entry to both buildings is strictly on presentation of
  a University Bodleian card.\n\n* The lecture is in person only\, and will
  start at 16:00 sharp. Seating is limited to 190 attendees.\n\n* Please no
 te that late arrivals cannot be accommodated.\n\nLecture abstract:\nABC tr
 ansporters are ATP-powered membrane proteins that are ubiquitous across bi
 ology\, with more than 80 members in E. coli and 48 in humans. Despite sha
 ring a common architectural framework\, these transporters carry out remar
 kably diverse functions. In this talk\, I will highlight three features th
 at make ABC transporters particularly fascinating. First\, their substrate
 s range from small ions and chemicals to lipids and large proteins\, spann
 ing systems that are exquisitely selective to those that are broadly promi
 scuous. Second\, ABC transporters function as both importers and exporters
 \, raising fundamental questions about how transport directionality is enc
 oded within a shared mechanism. Finally\, I will discuss CFTR\, an unusual
  member of the ABC family that functions not as an active pump but as a pa
 ssive ion channel. Together\, these examples illustrate how a conserved mo
 lecular machine has been adapted to serve diverse biological roles.\n\nJue
  Chen is the William E. Ford Professor and head of the Laboratory of Membr
 ane Biology and Biophysics at Rockefeller University. Her research program
  focuses on the comprehensive analysis of ABC transporters and the applica
 tion of these mechanistic insights to improve human health. Her recent stu
 dies include the cystic fibrosis conductance regulator (CFTR)\, the transp
 orter associated with antigen processing (TAP)\, and the multidrug transpo
 rters P-glycoprotein and MRP1.\n\nProfessor Chen received her Bachelor of 
 Science in Chemistry from Ohio University in 1993 and her PhD in Biochemis
 try from Harvard University in 1998\, where she was advised by the late Dr
  Don C. Wiley. She completed her postdoctoral work at Baylor College of Me
 dicine under the guidance of Dr Florante A. Quiocho. In 2002\, she joined 
 Purdue University as a faculty member and moved to the Rockefeller Univers
 ity in 2014. She was named a Pew Scholar in 2003 and has been an investiga
 tor at the Howard Hughes Medical Institute since 2008. In 2019\, she was e
 lected to the National Academy of Sciences.
LAST-MODIFIED:20260505T150247Z
LOCATION:Sherrington Building - Blakemore Lecture Theatre\, Blakemore Lect
 ure Theatre Sherrington Building off Parks Road Oxford Oxfordshire OX1 3PT
  United Kingdom
SPEAKER:Professor Jue Chen
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