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SUMMARY:DPAG Neuroscience Seminar: 'Plasticity of human astrocytes: How co
 ntext-dependent reactivity is regulated and can drive diagnostic and thera
 peutic innovation'
DTSTART;TZID=Europe/London:20260626T130000
DTEND;TZID=Europe/London:20260626T140000
DTSTAMP:20260523T075454Z
UID:85b0797f-c726-f111-88b4-6045bd12f634
CREATED:20260323T144938Z
DESCRIPTION:Astrocytes are highly heterogeneous and remarkably adaptable c
 ells that reshape their molecular and functional identities in response to
  brain injury. Distinct astrocyte subpopulations within the human brain pa
 renchyma exhibit reactive states that depend on their localization\, the t
 ype of injury\, microenvironmental cues\, and exposure to modulators from 
 non-neuronal sources such as blood and cerebrospinal fluid. By integrating
  multi-omic\, spatial\, and functional analyses across preclinical experim
 ental models and patient-derived tissue samples\, we are uncovering the si
 gnaling pathways that govern pathology-associated astrocyte plasticity\, i
 ncluding those that regulate the emergence of stem cell properties after b
 rain injury in mice and humans. Moreover\, age-related modifications furth
 er influence the capacity of this endogenous regenerative cell source\, un
 derscoring the need to understand how context-specific astrocyte adaptivit
 y can be fine-tuned across the lifespan. In this talk\, I will discuss not
  only our recent findings showing that astrocyte plasticity can be targete
 d to unlock regenerative potential in the adult human brain\, but also how
  this capacity may drive diagnostic and therapeutic innovation.
LAST-MODIFIED:20260415T085954Z
LOCATION:Sherrington Building - Sherrington Library\, Sherrington Library 
 Sherrington Building off Parks Road Oxford Oxfordshire OX1 3PT United King
 dom
SPEAKER:Professor Svetlana Sirko (Ludwig Maximilian University of Munich)
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