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SUMMARY:Controlled Human Challenge
DTSTART;TZID=Europe/London:20260511T120000
DTEND;TZID=Europe/London:20260511T130000
DTSTAMP:20260508T151856Z
UID:8df57938-5d3d-f111-88b4-6045bdcfe41f
CREATED:20260421T083651Z
DESCRIPTION:This will be a joint seminar between Professor Helen McShane a
 nd Dr Jonathan Pugh.\n\nProfessor Helen McShane - Establishing Controlled 
 Human Infection Models for Old and New Pathogens - Controlled human infect
 ion models\, where healthy participants consent to be deliberately exposed
  to a pathogen under carefully controlled clinical conditions\, are invalu
 able tools in vaccine R&D\, particularly for complex pathogens such as Myc
 obacterium tuberculosis. Unlike most human challenge models which use viru
 lent organisms\, it would not be ethical to deliberately infect healthy pa
 rticipants with virulent Mycobacterium tuberculosis. We have established a
  human challenge model using BCG\, a live attenuated strain of Mycobacteri
 um bovis that is licensed for human use. More recently we have established
  a human challenge model for SARS CoV-2 which allows the identification of
  immune correlates of protection. \n\nDr Jonathan Pugh - Ethical Considera
 tions in Designing Human Challenge Studies - In my contribution to the sem
 inar\, I will outline some of the ethical dimensions that should be taken 
 into account when aiming to design an ethical human challenge trial\, draw
 ing on recent work in research ethics.
LAST-MODIFIED:20260421T084201Z
LOCATION:Kennedy Institute of Rheumatology - Kennedy Lecture Theatre\, Ken
 nedy Lecture Theatre Kennedy Institute of Rheumatology Headington Oxford O
 xfordshire OX3 7FY United Kingdom
SPEAKER:Professor Helen McShane (University of Oxford)\, Dr Jonathan Pugh 
 (University of Oxford)
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