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DTSTART:19700329T010000
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SUMMARY:Controlling speed of cell decisions: molecular mechanisms harnessi
 ng criticality and transient dynamics
DTSTART;TZID=Europe/London:20260515T110000
DTEND;TZID=Europe/London:20260515T120000
DTSTAMP:20260515T121304Z
UID:9ac11596-9044-f111-bec7-7c1e52046848
CREATED:20260430T123211Z
DESCRIPTION:Cells make decisions across developmental biology\, immunology
 \, and synthetic biology. These processes are typically described using sy
 stems of ordinary differential equations\, where mathematical analysis foc
 uses on steady-state solutions. However\, understanding how the timing of 
 cell decisions is controlled requires moving beyond this paradigm. In this
  talk\, I will discuss two complementary molecular mechanisms for controll
 ing dynamical speed. First\, I will show how timing can be regulated throu
 gh critical slowing down\, and how combining different bifurcations can ge
 nerate emergent temporal behaviours even in small gene regulatory network
 s. Secondly\, I will address developmental tempo\, where embryos from dif
 ferent species execute remarkably similar genetic programmes at different 
 speeds. I will present a mathematical framework based on orbit invariance 
 that allows us to explore potential molecular mechanisms underlying specie
 s-specific differences in developmental timing.
LAST-MODIFIED:20260430T123439Z
LOCATION:Mathematical Institute - L4\, L4 Mathematical Institute Woodstock
  Road Oxford Oxfordshire OX2 6GG United Kingdom
SPEAKER:Dr Ruben Perez-Carrasco (Department of Life Sciences\, Imperial Co
 llege London)
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