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SUMMARY:Deadly pSIN: proteomic smoking index captures the biological impri
 nt  of smoking\, predicts disease risk and identifies key risk modifiers i
 n the UK biobank
DTSTART;TZID=Europe/London:20260602T130000
DTEND;TZID=Europe/London:20260602T140000
DTSTAMP:20260515T141740Z
UID:bb284885-b53c-f111-88b4-7ced8d9a5614
CREATED:20260420T123624Z
DESCRIPTION:Bio:\nCornelia's research within the Oxford Big Data Institute
  focuses on large-scale –omics studies of neurodegenerative disorders in
 cluding Alzheimer\, Parkinson and Creutzfeldt–Jakob disease and ophthalm
 ological disorders including glaucoma\, age-related macular degeneration a
 nd myopia.\n\nShe further studies systemic vascular\, endocrine and gastro
 intestinal pathology that is relevant for brain and ocular function. Her c
 urrent research portfolio includes cross-omics research integrating (epi)g
 enetic\, transcriptomic\, proteomic\, metabolomic and microbiome data of e
 pidemiological cohorts with state of the art brain imaging and cellular mo
 del systems.\n\nOver the  years\, Cornelia has been a leading figure in se
 veral international consortia including ENGAGE (European Network for Genet
 ic and Genomic Epidemiology)\, CHARGE (Cohorts for Heart & Aging  Research
  in Genome Epidemiology)\, IGAP (International Genetics of Alzheimer Disea
 se Project\, ADSP  (Alzheimer Disease Sequencing Project) and IGGC (Intern
 ational Genetics of Glaucoma Consortium).\n\nAt present\, she is the leade
 r of two major consortia: the Horizon2020 CoSTREAM consortium aiming to un
 derstand the link between stroke and Alzheimer disease and the MEMORABEL G
 ut-Brain consortium aiming to unravel the role of the gut microbiome in Al
 zheimer disease and brain pathology.\n\nShe further leads the human proteo
 mics and metabolomics discovery research in the Innovative Medicine Initia
 tive (IMI) ADAPTED programme\, which aims to identify new Alzheimer medici
 nes through understanding the function of the APOE gene. Cornelia is a mem
 ber of the Royal Netherlands Academy of Arts and Sciences (KNAW) and the N
 etherlands Council for Medical Sciences (RMW).\n\nCornelia studied Human N
 utrition and Mathematical Statistics at the Agricultural University of Wag
 eningen and Genetics and Epidemiology at the Erasmus University Medical Sc
 hool.\n\nThere will be tea/coffee and cake available in the atrium 30 min 
 before the seminar.
LAST-MODIFIED:20260420T123839Z
LOCATION:Richard Doll Building - Lecture Theatre\, Lecture Theatre Richard
  Doll Building Old Road Campus Oxford Oxfordshire OX3 7LF United Kingdom
SPEAKER:Professor Cornelia van Duijn (NDPH)
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