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SUMMARY:Quantitative genetic and epigenetic lineage tracing of blood in th
 e decades preceding leukaemia diagnosis
DTSTART;TZID=Europe/London:20260623T093000
DTEND;TZID=Europe/London:20260623T103000
DTSTAMP:20260606T083413Z
UID:c9688d4a-ce60-f111-a826-7ced8d9a5614
CREATED:20260605T110421Z
DESCRIPTION:For our next talk\, in the BDI/CHG (gen)omics Seminar series\,
  we will be hearing from Prof. Jamie Blundell\, Ursula Zoellner Professor 
 of Cancer Research at the Early Cancer Institute at the University of Camb
 ridge and a UKRI future leaders fellow. We’re delighted to host Jamie in
  what promises to be a great talk!\n\nDate: Tuesday 23 June\nTime: 9:30 am
  – 10:30 am\nTalk title: Quantitative genetic and epigenetic lineage tra
 cing of blood in the decades preceding leukaemia diagnosis\nLocation: Big 
 Data Institute\, Seminar Room 0\n\nAbstract\nMany human tissues are mainta
 ined by large numbers of long-lived stem cells. Positive and negative sele
 ction on somatic mutations that occur in these stem cells can drive rapid 
 evolution in human tissues over timescales of years to decades with import
 ant implications for future cancer risk. Blood is an ideal system for gain
 ing a quantitative understanding of these dynamics because it is easily sa
 mpled\, less spatially structured relative to other tissues and genomicall
 y well characterised. Here I will describe work that exploits unique colle
 ctions of serial blood samples from people destined to develop future bloo
 d cancers to reveal quantitative insights into this evolutionary process. 
 By performing high resolution lineage tracing of genetic and epigenetic ma
 rks we can time the key driving events in the evolution of Acute Myeloid L
 eukaemia\, estimate fitness effects of clones throughout the full disease 
 trajectory\, and characterise competition between clones. These data shed 
 light on the evolutionary dynamics occurring in pre-cancerous stem cells a
 nd suggest that many aspects of the observed dynamics can be understood wi
 thin a surprisingly simple framework of clonal evolution with competition\
 n\nBio\nJamie is the Ursula Zoellner Professor of Cancer Research at the E
 arly Cancer Institute at the University of Cambridge and a UKRI future lea
 ders fellow. He obtained his PhD in theoretical physics at Cambridge befor
 e moving to Stanford to undertake postdoctoral research in quantitative bi
 ology with Daniel Fisher and Dmitri Petrov in which he developed new ways 
 of measuring and clonal evolution. He established his lab in Cambridge in 
 2017 with a focus on the somatic evolution that occurs in healthy tissues 
 as we age and how this evolution is altered at the earliest stages of canc
 er. The lab also has an active interest in quantitative immunology particu
 larly in T-cell antigen recognition.
LAST-MODIFIED:20260605T110748Z
LOCATION:Big Data Institute - Lower Ground Seminar Room 0\, Lower Ground S
 eminar Room 0 Big Data Institute Old Road Campus Oxford Oxfordshire OX3 7L
 F United Kingdom
SPEAKER:Professor Jamie Blundell (University of Cambridge)
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