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SUMMARY:DPAG Neuroscience Seminar: 'Gene-environment interactions modulati
 ng brain function within and between generations'
DTSTART;TZID=Europe/London:20260721T160000
DTEND;TZID=Europe/London:20260721T170000
DTSTAMP:20260626T205739Z
UID:d3e35e33-4463-f111-ab0d-7c1e52046848
CREATED:20260608T141330Z
DESCRIPTION:We are interested in how gene-environment interactions mediate
  and modulate brain function\, in health and disease. Our findings have re
 vealed key pathways implicated in the therapeutic impacts of environmental
  stimuli and identified novel therapeutic targets. We have also discovered
  altered brain-body interactions\, including the first evidence of gut dys
 biosis (dysregulated gastrointestinal microbiota) in Huntington’s diseas
 e (where we model depression\, dementia and motor symptoms) and a genetic 
 model of schizophrenia. Furthermore\, we have shown that high-fibre diet a
 nd prebiotic interventions improved gut function and ameliorated cognitive
  and affective dysfunction. Ongoing studies are exploring the gut microbio
 me as a therapeutic target and the possibility that specific environmental
  factors may modulate brain function via microbiota-gut-brain interactions
 . These approaches to gene-environment interactions may facilitate the dev
 elopment of enviromimetics (including exercise mimetics as a subclass) for
  various brain disorders.\n\nIn order to understand how gene-environment i
 nteractions may sculpt brain development and function between generations\
 , we have also been exploring epigenetic inheritance via the paternal line
 age. We have discovered intergenerational effects of various paternal expo
 sures\, including exercise\, stress\, infection\, immune activation\, anti
 biotics and other drugs. These lifestyle factors and experiences modulate 
 sperm noncoding RNAs and alter offspring phenotypes. We are exploring epig
 enetically mediated changes in the brains of offspring. The effects on off
 spring\, including modulation of brain function and behaviour\, via epigen
 etic inheritance\, have particular relevance to the pathogenesis of depres
 sion and anxiety disorders.
LAST-MODIFIED:20260608T141631Z
LOCATION:Sherrington Building - Sherrington Library\, Sherrington Library 
 Sherrington Building off Parks Road Oxford Oxfordshire OX1 3PT United King
 dom
SPEAKER:Professor Anthony Hannan (University of Melbourne)
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