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SUMMARY:Prof Beth Psaila - Exploring the MEGAverse - new insights into meg
 akaryocytes and platelets\, and their roles in cancer
DTSTART;TZID=Europe/London:20260715T123000
DTEND;TZID=Europe/London:20260715T133000
DTSTAMP:20260626T205952Z
UID:efb1b259-3860-f111-a826-7c1e52046848
CREATED:20260604T171103Z
DESCRIPTION:Megakaryocytes are very large\, rare bone marrow cells that pr
 oduce platelets\, the tiny cell fragments in our blood that help with clot
 ting. Although platelets do not have their own nucleus (where genetic mate
 rial is stored in most of our cells)\, we recently discovered that they ca
 n pick up small pieces of DNA from the bloodstream\, including DNA release
 d by cancer cells and from a developing foetus.\nOur research looks at how
  megakaryocytes grow so large and copy their DNA many times without dividi
 ng\, and what this means for the stability of their genetic material. Mega
 karyocytes also play an important role in myeloproliferative neoplasms\, o
 r MPNs\, a group of chronic blood cancers that affect around 4\,000 people
  in the UK each year. We are studying how megakaryocytes communicate with 
 cancer stem cells and surrounding bone marrow cells\, and how these intera
 ctions may cause the disease to worsen\, especially into a condition calle
 d myelofibrosis. Understanding these interactions helps shed light on the 
 best approaches to develop more effective therapies.
LAST-MODIFIED:20260604T171549Z
SPEAKER:Prof Bethan Psaila (University of Oxford)
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