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SUMMARY:Mechanisms of Tumour Genome Evolution
DTSTART;TZID=Europe/London:20260518T120000
DTEND;TZID=Europe/London:20260518T130000
DTSTAMP:20260515T141903Z
UID:f3b56468-7a4f-f111-bec7-6045bd12f634
CREATED:20260514T095102Z
DESCRIPTION:We are pleased to invite you to attend our next external semin
 ar\, with Sarah McClelland\, PhD\, Professor of Cancer Cell Biology and Ge
 nomics\, Barts Cancer Institute\, Queen Mary University of London.\n\nSara
 h McClelland is Professor of Cancer Cell Biology and Genomics at the Barts
  Cancer Institute\, Queen Mary University of London and Deputy Centre Lead
  for Cancer Genomics and Computational Biology. Sarah studied Biochemistry
  and obtained her PhD in Biochemistry from the University of Bristol. Her 
 lab aims to understand the mechanisms that underlie numerical and structur
 al chromosome aberrations in cancer at a molecular level\, which also invo
 lves understanding how normal cells replicate and segregate their genomes.
 \n\nMechanisms of Tumour Genome Evolution\nAneuploidy and DNA copy number 
 variations are defining features of nearly all cancer types. Despite this\
 , very little is known about the mechanisms that cause these aberrations t
 o accumulate\, and what their functional significance is to cancer develop
 ment and therapy resistance. \n\nTo tackle these two fundamental challenge
 s\, we combine approaches from cell biology and genomics: \n-	First\, we d
 efine the mechanisms that cause chromosomal instability and aneuploidy in 
 cancer by characterising the acute genomic alterations that occur as a res
 ult of specific chromosomal instability mechanisms after one cell cycle. \
 n-	Second\, we track the genomic alterations at the single cell level as t
 he cancer cells grow – giving insights into patterns of ongoing genome e
 volution beyond traditional static sequencing approaches. \n-	Lastly\, we 
 employ a recently developed Cas9¬based experimental tool\, that induces c
 hromosomal mis¬segregation during mitosis\, to study the impact of specif
 ic chromosomal alterations on cellular behaviour.\n\nThis seminar will be 
 chaired by Dr Eileen Parkes and Dr Wei-Ting Lu.\n\nJoin the seminar: https
 ://teams.microsoft.com/meet/328951451608188?p=uWObCWbzetrxbH95w4 \nMeeting
  ID: 328 951 451 608 188 \nPasscode: 7re6so2J
LAST-MODIFIED:20260514T095304Z
LOCATION:Old Road Campus Research Building - Oncology Education Hub\, Onco
 logy Education Hub Old Road Campus Research Building Headington Oxford Oxf
 ordshire OX3 7DQ United Kingdom
SPEAKER:Professor Sarah McClelland (Barts Cancer Institute\, Queen Mary Un
 iversity of London)
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