BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//ox.ac.uk//NONSGML oxford.event//EN
X-WR-TIMEZONE:Europe/London
BEGIN:VTIMEZONE
TZID:Europe/London
X-LIC-LOCATION:Europe/London
BEGIN:DAYLIGHT
DTSTART:19700329T010000
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:BST
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:19701025T020000
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:GMT
TZOFFSETFROM:+0100
TZOFFSETTO:+0000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
SUMMARY:Ndd-mediated nucleoid disruption
DTSTART;TZID=Europe/London:20260515T110000
DTEND;TZID=Europe/London:20260515T120000
DTSTAMP:20260515T142004Z
UID:f823e4ce-ed33-f111-88b5-7c1e52046306
CREATED:20260409T082635Z
DESCRIPTION:Bacteria are protected by a diverse arsenal of antiviral defen
 ses that create a strong barrier against phage infection\, and the initial
  stages of infection are often critical for establishing an efficient infe
 ction cycle. In the T4 phage\, the early protein Ndd has been known for de
 cades to trigger a unique reorganization of the host nucleoid\, but its me
 chanism and biological significance remains unknown. Unlike any other know
 n phage system\, it forces the bacterial chromosome to redistribute and co
 at the inner cytoplasmic membrane\, though the molecular mechanism and bio
 logical significance of this extreme spatial segregation remain unknown.\n
 \nHere we show that Ndd is a sequence-specific DNA-binding protein that re
 models the host chromosome through hierarchical binding and multivalent DN
 A clustering\, leading to nucleoid disruption\, transcriptional shutdown a
 nd loss of higher-order genome organization. Ndd function also appears cou
 pled to phage immune evasion. These findings identify Ndd as a phage-encod
 ed chromosomal organizer that both dismantles host genome architecture and
  helps T4 overcome bacterial defences\, revealing a mechanistic link betwe
 en nucleoid remodelling and phage survival.
LAST-MODIFIED:20260428T072601Z
LOCATION:Dorothy Crowfoot Hodgkin Building - Seminar Room 2 (Room 20-138)\
 , Seminar Room 2 (Room 20-138) Dorothy Crowfoot Hodgkin Building off South
  Parks Road Oxford Oxfordshire OX1 3QU United Kingdom
SPEAKER:Dr Romain Koszul (Institut Pasteur\, Paris)
END:VEVENT
END:VCALENDAR