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SUMMARY:Dissecting the human placenta-endometrium niche in vitro
DTSTART;TZID=Europe/London:20260602T130000
DTEND;TZID=Europe/London:20260602T140000
DTSTAMP:20260601T150634Z
UID:f8501046-be5d-f111-a825-7ced8d99a758
CREATED:20260601T133210Z
DESCRIPTION:Abstract:\nThe placenta is essential for nutrient and gas exch
 ange between mother and foetus\, and its proper development is critical fo
 r pregnancy success. To overcome the lack of physiologically relevant mode
 ls\, we established a tissue-engineered system that recapitulates the rece
 ptive endometrium and supports early postimplantation development of human
  embryos and stem cell–derived blastoids. This platform enables advanced
  trophoblast differentiation\, including trophoblast plate and villus form
 ation\, providing a powerful tool to study the molecular mechanisms regula
 ting the placenta–endometrium niche.\nShort bio:\nDr Irene Zorzan comple
 ted her undergraduate and master’s degree in Molecular Biology at the Un
 iversity of Padova. Her fascination with developmental biology has underpi
 nned her academic career choices from the beginning. To fulfil this intere
 st\, she carried out her PhD studies in Prof. Graziano Martello’s lab at
  the University of Padova. Her research examined the molecular control of 
 human embryonic development using human pluripotent stem cells (hPSCs). To
 wards the end of her PhD studies\, she became captivated by the developmen
 t of the placenta. She therefore developed a method to convert hPSCs to tr
 ophoblast stem cells in an efficient and rapid manner. To pursue her inter
 ests in human development and gene regulation\, she joined Peter Rugg-Gunn
 ’s team at the Babraham Institute in 2021. Here\, she has developed new 
 approaches to study human postimplantation development. Supported by a Lev
 erhulme Early Career
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