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SUMMARY:The ECM viscoelasticity controls tissue spatiotemporal dynamics
DTSTART;TZID=Europe/London:20261120T110000
DTEND;TZID=Europe/London:20261120T120000
DTSTAMP:20260813T175545Z
UID:fb991006-6692-f111-8077-6045bdc13891
CREATED:20260807T134352Z
DESCRIPTION:The acquisition and maintenance of the correct cellular patter
 n and tissue architecture is essential for organ function in multicellular
  organisms. Beyond generating the required cellular diversity\, developing
  tissues need to attain the appropriate morphology. Tissue architecture is
  built through symmetry breaking instabilities such as folding\, branching
 \, buckling or budding. Studying single-cell responses alone is not enough
  to reveal the mesoscale physical and biochemical processes that regulate 
 tissue organization and morphology over time and scale. In our lab we inve
 stigate how the interaction between the extracellular matrix (ECM) and tis
 sues regulates processes during development and cancer\, with a focus on E
 CM mechanical properties. While most research in this domain has concentra
 ted on the ECM's elasticity as a primary determinant of cell and tissue be
 haviour\, it is important to note that the ECM possesses both viscous and 
 elastic properties. I will present our findings demonstrating that the pas
 sive viscoelastic properties of the ECM regulate tissue architecture and p
 atterning both during development and cancer. Specifically\, we show that 
 ECM viscoelasticity influences the spatial and temporal organization of mu
 lticellular tissues in breast and intestinal organoids. Overall\, our work
  highlights the critical role of viscoelasticity in driving morphological 
 symmetry breaking instabilities\, a fundamental process in morphogenesis a
 nd oncogenesis\, and suggests ways of controlling tissue through ECM mecha
 nics.
LAST-MODIFIED:20260807T134731Z
LOCATION:Mathematical Institute - L4\, L4 Mathematical Institute Woodstock
  Road Oxford Oxfordshire OX2 6GG United Kingdom
SPEAKER:Dr Alberto Elosegui-Artola (The Francis Crick Institute)
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