Decoding T cell specificity at scale

Thursday, 4 June 2026, 3pm to 4pm

Dr. Stephanie Gaglione is a postdoctoral scholar in the Marson lab at the UCSF-Gladstone Institute of Genomic Immunology. She completed her PhD at MIT with Michael Birnbam engineering high-throughput tools to synthesize and screen T cell receptors in the context of autoimmunity and cancer. Her work introduced an approach to reconstruct thousands of T cell receptors from sequences and map them against hundreds of antigens simultaneously, identifying autoreactive T cells in vitiligo lesions with transcriptomic signatures akin to T cells in melanoma. She expanded on this approach to examine T cell cross-reactivity, profiling millions of mutated TCRs against many antigens simultaneously to map the TCR-antigen interface. Stephanie is a Dunn School alum, previously working with Omer Dushek.

Speaker(s): Dr Stephanie Gaglione (Gladstone Institute, San Francisco, USA)

Series: Dunn School of Pathology Research Seminars

Venue: Sir William Dunn School of Pathology - EPA Seminar Room - EPA Seminar Room Sir William Dunn School of Pathology South Parks Road Oxford Oxfordshire OX1 3RE United Kingdom

Department: Pathology Dunn School (Department)

Organiser: Melissa Wright

Host: Prof Omer Dushek