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Genetic and Epigenetic Regulation of Synovial Fibroblasts in Rheumatoid Arthritis

Audience: Member of University - ALL Format: In Person
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Monday, 20 July 2026, 12pm to 1pm

This seminar will present recent advances in our understanding of the genetic and epigenetic regulation of synovial fibroblasts in rheumatoid arthritis (RA). The role of DNA methylation and chromatin organisation in shaping pathogenic fibroblast phenotypes will be discussed, and the role of RA genetic risk loci in altering fibroblast functions will be explored. Finally, emerging approaches for identifying functional regulatory elements and candidate therapeutic targets will be discussed, providing a broad perspective on the genetic and epigenetic drivers of fibroblast activation in RA.

Speaker(s): Professor Caroline Ospelt (University of Zurich)

Series: Kennedy Institute of Rheumatology External Seminar Series

Venue: Kennedy Institute of Rheumatology - Kennedy Lecture Theatre - Kennedy Lecture Theatre Kennedy Institute of Rheumatology Headington Oxford Oxfordshire OX3 7FY United Kingdom

Department: Kennedy Institute of Rheumatology (Unit)

Organiser: Tess Lawless

Host: Professor Christopher Buckley