Nuclear Mechanotransduction in Genome Integrity & Malignant Transformation

Monday, 18 May 2026, 12pm to 1pm

Nuclear architecture coordinates patterns of gene expression and mediates cell identity and state. Nuclear architecture and shape are also fundamentally altered in most cancers and these abnormalities are routinely used to diagnose cancer and stage its aggressiveness. However, the causes and direct consequences of nuclear shape alterations in both healthy and diseased states have remained unclear. Using chromosome mis-segregation driven aneuploidy and colorectal cancer (CRC) as models we have study the roles of nuclear mechanics and deformation in cell state regulation, malignant transformation and cancer progression. In my presentation I will discuss our recent research on how cells sense nuclear deformation and mechanical changes and how these mechanosignals are integrated with biochemical inputs to alter cell behaviors and tune disease outcome.

Speaker(s): Dr. Yekaterina (Kate) Miroshnikova (Max Planck Institute for Molecular Biomedicine, Muenster, Germany)

Venue: Kennedy Institute of Rheumatology - Kennedy Lecture Theatre - Kennedy Lecture Theatre Kennedy Institute of Rheumatology Headington Oxford Oxfordshire OX3 7FY United Kingdom

Department: Kennedy Institute of Rheumatology (Unit)

Organiser: Tess Lawless

Host: Dr Adrien Hallou